Peak-based TF motif enrichment Z-test

Wrapper function to assess a specific set of peaks for enrichment with respect to TF binding motifs using a Z test after adjusting for GC bias and Tn5 accessibility

Usage

motifPeakZtest(peakSet, bgPeaks, tfMat)

Arguments

peakSet

vector of peak indices you wish to test for motif enrichment

bgPeaks

background peaks matrix returned by getBackgroundPeaks function in chromVAR

tfMat

binary match sparseMatrix object of (reference) peaks by TF motifs returned by matchMotifs function

Value

data frame of motif enrichment results rank sorted by significance and frequency of motifs in the peakset, respectively

Author

Vinay Kartha, Samuel Rose, and Jason D. Buenrostro